Simultaneous Electrochemical Determination of Paracetamol and Folic Acid at Pregabalin Modified Carbon Paste Electrode: A Cyclic Voltammetric Study


In this study, the electrochemical sensor was fabricated for the detection of paracetamol and folic acid by modifying the carbon paste electrode using Pregabalin drug. The fabricated carbon paste electrode was characterized by cyclic voltammetry; the result shows an excellent enhanced elctrocatalytic activity of the modified electrode towards paracetamol and folic acid with combined selectivity and sensitivity. Several kinetic parameters such as area of electrode, nature of electrode process and limit of detection were calculated. The modified carbon paste electrode can successfully use for the determination of paracetamol and folic acid individually and collectively. The limit of detection was found to be 0.093 × 10-5 M, 0.201 × 10-5 M for paracetamol and folic acid respectively. The fabricated electrode can successfully have applied for the detection of paracetamol in pharmaceutical preparations.